Scientists at the University of Illinois Springfield and Southern Illinois University School of Medicine are teaming up to investigate how certain cells in the body connect and encourage the spread of cancer.

The project, led by Natalya Zinkevich, UIS assistant professor of integrated sciences, and Sophia Ran, SIU professor of medical microbiology, immunology and cell biology, focuses on two types of cells – immune cells from bone marrow and specialized cells from the lymphatic system – and how these cells interact.

The team uses fluorescent microscopy to observe these interactions. One cell-type glows red and the other green. When the cells fuse, they produce a yellow fluorescence, which helps scientists observe how often fusion occurs, its role in tumor formation and how potential cancer therapies might impact this process.

“Our goal is to understand how cancer spreads and identify ways to prevent tumor growth,” Zinkevich said. “As part of this project, students will also gain hands-on experience in cell culture techniques at UIS, preparing them for additional research opportunities at SIU during the summer.”

Ran described the partnership as an opportunity to extend research collaboration between UIS and SIU while providing valuable training for three undergraduate students.

“I think this collaboration will open a new avenue for research training for UIS undergraduates and advance an important scientific discovery that can change our understanding of tumor spread mechanisms,” Ran said.

UIS sophomore biology major Frankie Molitor, who plans to attend medical school to become an anesthesiologist, emphasized how the research has advanced her academic and career goals.

“This research has provided valuable hands-on experience with cell culture techniques, allowing me to gain skills that are essential in cell biology and research,” Molitor said. “The work will help me understand how cellular signaling influences important processes like cell division and tumor suppression.”

Senior pre-med biology major Isabella Wade started working on the project this semester and is excited to play a role in cancer research.

“Just knowing that we could make even a small contribution to fight this disease is a fulfilling opportunity,” she said.

The Caryl Towsley Moy, Ph.D., Endowed Fund for Collaborative Research is funding the research. It supports team-based research between UIS and SIU School of Medicine faculty through a competitive selection process. Moy’s family established the fund to honor her work at both institutions.